In the ever-evolving world of aesthetic medicine, polynucleotide-based treatments have emerged as a game-changer for those seeking natural, long-lasting skin improvement. Leading the charge is the Plinest range, developed by Italian pharmaceutical company Mastelli. Known for its innovative use of highly purified polynucleotides (PN-HPT™), Plinest goes beyond traditional fillers or Botox by promoting true skin regeneration at a cellular level.

Unlike treatments that merely add volume or relax muscles, Plinest stimulates fibroblasts to boost collagen and elastin production, enhance hydration, improve elasticity, and repair damaged tissue. Derived from trout DNA and purified to pharmaceutical standards, these injectables are biocompatible, safe, and backed by over 100 clinical studies.

(Plinest product packaging examples: Plinest One, Plinest Hair, and Plinest Eye)

What Makes Plinest Unique?

Plinest utilizes PN-HPT™ (Highly Purified Technology) polynucleotides extracted from Italian trout fish. This patented process ensures exceptional purity and compatibility with human skin, minimizing risks and maximizing efficacy. The result? Skin that looks healthier, firmer, and more radiant from within—without artificial plumping.

Common benefits include:

  • Reduced fine lines and wrinkles
  • Improved skin texture and tone
  • Enhanced hydration and elasticity
  • Reduction in scars, stretch marks, and dullness
  • Anti-inflammatory effects for calmer skin

Treatments are minimally invasive, with little downtime, and results build gradually over weeks, lasting 6–12 months with maintenance.

The Plinest Product Range: Tailored Solutions for Every Concern

Mastelli’s Plinest line offers specialized formulations to target specific areas and needs. Here’s a breakdown of the key products:

Plinest (Standard/Regular)

  • Best for: Face, neck, décolletage, hands, and body
  • Key features: Pure polynucleotide gel for overall biorevitalization
  • Ideal for: General anti-aging, skin laxity, dullness, and acne scars

Plinest Eye

  • Best for: Delicate under-eye area
  • Key features: Targets periocular wrinkles, dark circles, bags, and sagging
  • Ideal for: Refreshing tired eyes and reducing crow’s feet

Plinest Hair

  • Best for: Scalp and hair follicles
  • Key features: Promotes hair growth and thickness
  • Ideal for: Hair thinning, alopecia prevention, and scalp health

Plinest Fast (or variants like Plinest One/Plus)

  • Best for: Sensitive/delicate areas, maintenance, or larger body zones
  • Key features: Lower concentration for quick recovery; some versions for post-procedure or broad application
  • Ideal for: Young skin, fine areas, stretch marks, or scars

Related: Newest (often grouped with Plinest) combines polynucleotides with hyaluronic acid for extra hydration and lift—perfect for dry or deeply wrinkled skin.

(Real-world before-and-after examples showcasing smoother texture, reduced wrinkles, and brighter skin from Plinest treatments)

What to Expect from a Plinest Treatment

A typical course involves 3–4 sessions spaced 2–3 weeks apart, followed by maintenance every 6 months. Injections are done with fine needles or cannulas by trained professionals. Mild redness or swelling may occur but resolves quickly.

Patients often report glowing, youthful skin that feels stronger and more resilient. It’s suitable for all skin types and ages, from preventive care in younger individuals to restorative treatments for mature skin.

Why Choose Plinest?

In a market flooded with options, Plinest stands out as the original polynucleotide pioneer since 2005. Its evidence-based approach delivers natural results that enhance your skin’s own healing power.

If you’re tired of temporary fixes and want genuine regeneration, the Plinest range could be your next step toward healthier, more vibrant skin. Always consult a qualified aesthetic practitioner to determine the best product for your needs.

Ready to glow from within? Explore Plinest today!